http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007016136-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74fc4583d847e0c4cceb7ce31194b3fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b04f067358421e8f3cf5f6d8e5313e07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D273-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C291-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 |
| filingDate | 2006-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c24c041bc4b7fe5d4bca534da38f3bd |
| publicationDate | 2007-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007016136-A2 |
| titleOfInvention | Organic nitric oxide enhancing salts of cyclooxygenase-2 selective inhibitors, compositons and methods of use |
| abstract | The invention describes compositions and kits comprising organic nitric oxide enhancing salts of cyclooxygenase 2 (COX-2) selective inhibitors, and compositions comprising at least one organic nitric oxide enhancing salt of a COX-2 selective inhibitor, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating inflammation, pain and fever; (b) treating gastrointestinal disorders and/or improving the gastrointestinal properties of COX-2 selective inhibitors; (c) facilitating wound healing; (d) treating renal and/or respiratory toxicities; (e) treating disorders resulting from elevated levels of cyclooxygenase-2; (f) improving the cardiovascular profile of COX-2 selective inhibitors; (g) treating diseases resulting from oxidative stress; (h) treating endothelial dysfunctions; (j) treating diseases caused by endothelial dysfunctions; (k) treating inflammatory disease states and/or disorders; (1) treating ophthalmic disorders; and (m) treating peripheral vascular diseases. The organic nitric oxide enhancing compounds that form salts with the COX-2 selective inhibitor are organic nitrates, organic nitrites, nitrosothiols, thionitrites, thionitrates, NONOates, heterocyclic nitric oxide donors and/or nitroxides. The heterocyclic nitric oxide donors are furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines. The organic nitric oxide enhancing salts of cyclooxygenase 2 selective inhibitors of the invention are organic nitric oxide enhancing salts of 2(2-((2-chloro-6-fluorophenyl) amino)5- methylphenyl)acetic acid derivatives. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9045505-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107847484-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010110684-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021113912-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-015092-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9994534-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010000019-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016151591-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9629859-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2009266408-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8822509-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107847484-A |
| priorityDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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