| abstract |
The present invention provides a process for preparing spherical pancreatin-containing granules, which comprises dispersing one or more divided portions of pancreatin in water to prepare one or more dispersions and spraying the dispersions on spherical granular cores while fluidizing the spherical granular cores in a fluidized-bed granulator, wherein the spraying is conducted within 20 to 90 minutes since the preparation of respective dispersions; and a process for preparing enteric-coated pancreatin-containing granules using the same. |