| abstract |
A compound represented by the formula (I) or a salt thereof: wherein E represents a cyclic group which may be substituted; D represents a carbonyl or sulfonyl group; A represents CH or N; the ring P represents a 5- to 7-membered ring which may be further substituted; the ring Q represents a 5- to 7-membered non-aromatic ring which may be further substituted; and the ring R represents a 5- to 7-membered non-aromatic ring which may be further substituted and which may be condensed. The compound has an ACC-inhibitory effect, is useful for the prevention/treatment of obesity, diabetes, hypertension, hyperlipemia, heart failure, diabetic complication, metabolic syndrome, sarcopenia and the like, and is excellent with respect to pharmacological efficacy, duration of action, specificity, low toxicity and the like. |