| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22e022678d7d82816abc3520f1cbf1e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e5fad41f12f3ecf696bcf0dff4c7763
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_799fd3cbbcda6b09e046a6dcd071271e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 |
| filingDate |
2006-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_867f85c9e0616f0c1dcc99d3c2e86f42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cdf2664e2778f2e64c8d4e2c693892e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e4a27825bdf1db7017037721f3d01e2 |
| publicationDate |
2007-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007013645-A1 |
| titleOfInvention |
Valacyclovir precursor, valacyclovir and salts thereof, and process for the production of them |
| abstract |
A process for the production of 2-[(2-amino-1,6-dihydro-6- oxo-9H-purin-9-yl)methoxy]ethyl N-[(benzyloxy)carbonyl]-L- valinate (3) (Z-valacyclovir) which comprises the step of condensing aciclovir (1) with N-[(benzyloxy)carbonyl]-L-valine (2) in the presence of a condensing agent in a solvent, characterized in that the aciclovir (1) takes the form of a powder having a mean particle diameter of 120µm or below. According to the process, Z-valacyclovir which is reduced in optical isomer content and enhanced in chemical purity can be produced, which makes it possible to provide chemically and optically high-purity 2-[(2-amino-1,6-dihydro-6-oxo-9H- purin-9-yl)methoxy]ethyl L-valinate (valacyclovir) or salts thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102718767-A |
| priorityDate |
2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |