| abstract |
The invention concerns a cell/ligand specific marking system, said system being characterized in that it comprises: (a) an endothelial precursor cell (EPC) including a cell marker selected among the group consisting of the Eph (in particular EphB4 or EphB1), and (b) a protein material of structure L-K, which consists of a ligand (L) specific of said marker and is associated or fused with a binding protein (K), said system being capable of providing a proangiogenetic cell material of structure EPC-Eph-L-K. The invention also concerns said cell material as product capable of stimulating angiogenesis, its preparation method and its therapeutic use, in particular with respect to vascular insufficiencies. |