http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007008693-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_308f7757c696166af2fecd70b93aa9ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d50d22fa02c87ccb4ea7c58b41483e5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2523-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 |
| filingDate | 2006-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a42376810496ad133c17681689ebe95b |
| publicationDate | 2007-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007008693-B1 |
| titleOfInvention | Gene methylation as a biomarker in sputum |
| abstract | A method to monitor the health of a subject comprising obtaining a test sample containing DNA from the subject; subjecting the DNA to bisulfite modification; expanding the number of copies of at least one gene selected from pi 6, MGMT, DAPK, PAX5-alpha, PAX5-beta, RASSFlA, DAB-2, DAL-I, RASSF2A, GATA5, and GAT A4 by using a polymerase chain reaction with a first primer set to amplify a portion of the gene where the promoter methylation resides, thereby generating an amplification product; using an aliquot of the amplification product generated by the first polymerase chain reaction in a second, methylation-specific, polymerase chain reaction with a second set of primers having a temperature of annealing that exceeds the melting temperature, to detect the presence of inactivation of the at least one specific gene selected from pi 6, MGMT, DAPK, PAX5-alpha, PAX5-beta, RASSFlA, DAB-2, DAL-I, RASSF2A, GATA5, and GATA to monitor the health of the subject. |
| priorityDate | 2005-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.