| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e4a46944184f2f5e8312187e1904304
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8f401141d15ab7708557a72b67c7313
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31113f255a0219638854405a2728b28f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94b51d317764e2f4f1bbcb355b274c8b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 |
| filingDate |
2005-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d8b3608e21152756d36c41b0907c62b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cc93cf6e9eebe3e25b6f83274f227ee |
| publicationDate |
2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007001455-A2 |
| titleOfInvention |
Hydrophobic polyamine amides as potent lipopolysaccharide sequestrants |
| abstract |
Lysine-spermine conjugates with a long-chain aliphatic (C12-C20) substituent at R1 bind and neutralize bacterial lipopolysaccharides. These compounds reduce lethality in a murine model of lipopolysaccharide-induced shock, and may serve as novel leads for developing novel anti- lipopolysaccharide agents for the therapy of Gram-negative sepsis. These compounds are represented by the formula (I): wherein X is 0 or H, H; R is a hydrophobic C12-C20 chain and Y is -NH2 or -H; and pharmaceutically acceptable salts thereof and prodrugs thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7939505-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11395834-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8877729-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501824-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9339461-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9731016-B2 |
| priorityDate |
2004-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |