| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22af0c923d7537d54c62e7b66d4dceed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_432957171abe4b5583ae20ec9a3894d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a1a1bb5c105608bee9d691d1cb6d79f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2fd517de3a4411013953c8fb7876c8c7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 |
| filingDate |
2005-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3007e15faa9337d088f90b0caa7baa05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac1eed9b47af90dac5a6e83cf257562d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2d99fed5de8b0842ee003e81da37c35 |
| publicationDate |
2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007001356-A2 |
| titleOfInvention |
Nanoparticles for cytoplasmic drug delivery to cancer cells |
| abstract |
The invention is a nanoparticle that contains an anticancer drug that is released in cancer cells when administered to a subject. The nanoparticles have a core including the anticancer drug and polymer chains that are soluble at the pH of the cancer cell. The core is surrounded by a layer of polymer chains that are insoluble at the pH of healthy tissue but soluble at the pH of the cancer interstitium. An outside layer is made of water-soluble polymer chains to shield the nanoparticle from RES recognition and give the nanoparticle a long circulation time in the bloodstream of the subject. The outside layer may also include folic acid moieties that bind folic acid receptors on the surface of the cancer cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10047072-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078755-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107375246-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107375240-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107375246-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9993438-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078804-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078803-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10577351-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078802-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8999382-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-018559-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11408903-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8765173-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078756-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078754-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8324274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-018636-B1 |
| priorityDate |
2004-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |