| abstract |
Compounds are disclosed that inhibit enzymes of the uracil base excision repair (UBER) pathway. Inhibitors of uracil DNA glycosylase, pUTPase and AP endonuclease I are disclosed. The compounds can comprise a uracil substrate fragment and a second binding element joined covalently together by a linker molecule. The compounds are also disclosed comprising a uracil substrate fragment, a second binding element, and a third binding element, which a joined together covalently by a linker molecule. Also disclosed are methods for treating diseases and disorders in a subject in need of treatment where the disorder and/or diseases include cancer and bacterial, viral, and parasitic infections and where the method includes the step of administering the disclosed inhibitors. The administered inhibitors inhibition the enzymes of the UBER pathway, thereby treating the diseases and disorders disclosed herein. |