| abstract |
The invention concerns a mutated nucleotide sequence, said mutated sequence being derived by mutation from a nucleotide sequence encoding a protein comprising or constituted by the Core protein or a fragment of the Core protein, and as the case may be the E1 protein and/or the E2 protein of the hepatitis C virus and/or one or more fragments of the E1 protein and/or of the E2 protein of the hepatitis C virus, said mutated nucleotide sequence being such that it encodes a reading frame 0 for said protein, but does not allow the expression of an ARFP protein or fragments of an ARFP protein of more than 11 amino acids, encoded in the reading frame +1 by said non mutated nucleotide sequence, for preparing a vaccine or a drug for preventing or treating infections related to the hepatitis C virus. |