| abstract |
The present invention relates to processes for the preparation of formula (I). These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. Compound (I), comprising the steps of: (Step 1) combining a compound (II) having the formula (II) with a compound (III) having the formula (III) in a solvent, optionally in the presence of a copper catalyst, to form a compound (IV) having the formula (IV); (Step 2) combining a compound (IV) with a compound (V) having the formula: (V) in a solvent in the presence of a reducing agent to form a compound (VI) having the formula (VI). |