| abstract |
Methods are disclosed for using peripheral blood mononuclear cells to evaluate vascular disease, such as predicting a subject's risk of vascular disease, determining a treatment regimen for a subject who has such as risk, or combinations thereof. Also provided are arrays and kits that can be used to practice the methods. In one example, the method includes screening for differential expression of vascular risk-related molecules, such as DNA binding/transcription factor proteins, lysosomal or protein degradation enzymes, adhesion molecules, metabolism molecules, intracellular signaling molecules, immune response molecules, and apoptosis. Also provided are methods of screening agents to determine their affect on expression of vascular risk-related molecules. |