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filingDate 2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6509cf1fe23326c727abdb8efb17aa1f
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publicationDate 2007-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2006128643-A3
titleOfInvention Supramolecular aggregates containing chelating agents and bioactive peptides as effective and selective delivery tools for drugs and contrast agents in mri or nuclear medicine
abstract The invention relates to supramolecular aggregates obtained by coaggregation of two monomers: - a first monomer containing a paramagnetic or radioactive metal ion complexed by a chelating agent having a lipophilic moiety, - a second monomer containing a bioactive peptide linked to a lipophilic moiety through an organic spacer. The aggregates are selectively driven by the exposed bioactive peptide on a desired biological target. The aggregates (micelles, vesicles or liposomes) could entrap on their inner region or on their surface a pharmaceutical active principle (drug). The invention thus relates to target specific delivery of drugs and/or metal ions. The invention therefore provides compositions containing said aggregates for use as contrast agents, in nuclear medicine or MRI, for the selective delivery of drugs, and for simultaneous delivery of a drug and a metal ion.
priorityDate 2005-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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