| abstract |
The present invention provides for a recombinant nucleic acid molecule comprising a humanized mouse /3-amyloid precursor protein ('APP') gene comprising K670N, M671L and V717F mutations and uses thereof. The present invention further provides for a recombinant nucleic acid molecule comprising a region of a calcium-calmodurin dependent kinase IlĪ± ('CaMKIIa') promoter operatively linked to a /3-amyloid precursor protein ('APP') gene comprising at least one mutation and uses thereof. |