| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db0708648c7fe01ed6962e61897fa081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e66070cbe19cee2a7e98dd43682126d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5134b709d680b30a7b96037e92320c6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8477d3efae88e8bc17263083ccf0495e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aed3f6a016c7746813df918102a434d1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90245 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5032 |
| filingDate |
2006-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3704761c9e072d55b69273f709fc419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_830faeca35415cdc9ce6553d4b4523de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b817fc50207065ed8ac069820914b1c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f81a0c776e554e27b3294eace7ddcbee |
| publicationDate |
2006-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006127731-A2 |
| titleOfInvention |
Inhibitors of pghs-2transactivator activity |
| abstract |
Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H2. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-κB regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7927799-B2 |
| priorityDate |
2005-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |