| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dd0759950a6de264b065af44e0f1840
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ac78bfc68fa3f1478982e7816428fd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55c95ff081ed4b304c0798621c7b0b3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01f4dfbf7e928b2477534a09534993e7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-735
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 |
| filingDate |
2006-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f206fa105e2882cb44bff0ea8974967
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_258a15c9522006f94c42541a9f2c18a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a9cff210cc53b8a18cde083a0e74ce4 |
| publicationDate |
2006-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006125963-A2 |
| titleOfInvention |
Modified leukocyte ig-like receptor family members (lir' s) with increased affinity for class i mhc and their uses in modulating t cell activation |
| abstract |
The present invention provides polypeptides having the property of binding to a given Class I pMHC CHARACTERISED IN THAT said polypeptide has a KD for the said given Class I pMHC of less than or equal to lμM and/or has an off-rate (koff) for the said given Class I pMHC molecule of 2 S-1 or slower AND said polypeptide has at least a 45 % identity and/or 55 % similarity to SEQ ID NO: 7 AND said polypeptide inhibits CD8 binding to the given pMHC to a greater extent than the polypeptide SEQ ID NO: 3. Such polypeptides are useful, either alone or associated with a therapeutic agent, for the inhibition of cyto-toxic T cell (CTL) responses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008062158-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008062147-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008062158-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009060159-A1 |
| priorityDate |
2005-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |