http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006125493-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2bcaf91101a370a3d64e3190366357f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d1b174da24b0ff2e1fa83412127905f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f2c913a4bdd38b158c7b3245282ccbb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2006-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fff75a39baec86cb3db9c74a2746d4d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc22acbcf92c48f891583b9a493bfe9e |
| publicationDate | 2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006125493-A3 |
| titleOfInvention | USE OF NOVEL HNF4α TARGET GENES AND THEIR GENE PRODUCTS |
| abstract | Dysfunction of HNP4alpha may lead to disease and an identification of genes targeted by this factor provides insights into mechanisms of disease. In accordance with the invention thirteen new HNF4alpha target genes were found (C20orfl3, KIAA0774, EPS15R, PLCB1, UGTREL1, RSK4, PAK5, FMR2, NEB, NFYC, KCNQ4, PRPF3, TRPC1). These genes were identified by means of molecular biological and molecular genetic methods. The genes code for various biological functions (metabolism, regulation of cell cycle and signal transduction, differentiation, ion channels, mRNA processing, see table A) and are thus important for the therapy of metabolic disorders, diabetic diseases and tumor growth. In the present invention, additionally eleven new HNF4alpha target genes are described. It was shown that HNF4alpha and TPRC1 are regulated in animal models of diabetes. Thus, TPRCl is a candidate gene for the treatment of diabetic nephropathy. The discovery of the above described target genes of HNF4alpha and their function comprises an enormous potential for the treatment of metabolic diseases including diabetes and diabetic caused diseases and tumor growth. |
| priorityDate | 2005-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.