| abstract |
A chewing gum comprising at least one active pharmaceutical ingredient (API) within the core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent (s) and result in the domination of flavoring agents in the coating (s) over flavoring agent (s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent (s) in the coating (s) and (b) achieving an increased control of the release of the API and of non-active excipients. |