| abstract |
The present invention provides novel statin derivatives and a facile process for preparation thereof selected from a group consisting of a compound of formula (I), wherein R is selected from a group consisting of -OH, -OR1, OCOR1, -OCHO, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, alkylaryl, heteroaryl, aralkyl, heterocycle having ring size between 3 to 6, -CN, -COOH, -COOR1, -CONHR1, -CONR1R2, -NH2, -NHR1, -NR1R2 halogen, -SH and -SR1; wherein R1 and R2 are independently selected from C1-C6 alkyl, alkylaryl, heteroaryl, aralkyl, heterocycle having ring size between 3 to 6, C2-C6 alkenyl and C2-C6 alkynyl, or R1 and R2 together with the carbon atom to which they are attached from a heterocycle with a ring size from 3 to 6, ------ represents either α or β-susbstituent, and pharmaceutically acceptable salt thereof. The compounds have anti-hyperlipidimic anti-hypercholesterolemic and antiinflammatory activity. |