abstract |
A rapid and sensitive radiometric assay for assessing the activity of cytochrome P-450 (CYP) 2C8 and the potential of an analyte to inhibit CYP2C8 activity or induce CYP2C8 expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated. |