abstract |
Provided are quinazoline derivatives of the compound (I), and its preparation process and application as a medicine of inhibit tumor growth. The group X, Y, Z, R1, R2, R3, R4 of compound (I) are defined in the description. Compounds of the invention can specially inhibit tyrosine kinase activity, inhibit the activity of two high-affinity receptors of VEGF, adjust VEGF secretion, thus to have to achieve the purpose of treating malignant tumor. |