| abstract |
The invention features a method for identifying a compound that inhibits apoptosis (e.g., ER stress-induced apoptosis). This method includes the steps of (a) contacting a polypeptide having a HIAP2 BIR2 or HIAP2 BIR1-BIR2 linker region (e.g., a human HIAP2 BIR2 or HIAP2 BIR1-BIR2 linker region) with a candidate compound; and (b) determining whether the candidate compound binds the polypeptide. |