| abstract |
The present invention provides compositions, methods and kits useful for the diagnosis and treatment of Alzheimer's disease (AD). In particular, the invention provides polypeptides and metabolites that are markers of AD, polynucleotides that encode the polypeptides and antibodies that specifically bind to the polypeptides. The invention also provides fragments, precursors, successors and modified versions of the foregoing polypeptides, metabolites, polynucleotides and antibodies. The invention also provides compositions comprising the foregoing polypeptides, metabolites, polynucleotides and antibodies. The invention also provides methods for using the polypeptides, metabolites, polynucleotides and antibodies in the diagnosis and treatment of AD, monitoring progression of the disease and screening of candidate therapeutic compounds. |