http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006105993-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66c1b22707b0276e3078713a6ddcba91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_734332134d4de9ebe1ba07ccf2c13596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79d06cf93d29c6210a9048bebbc8dc1b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2006-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_148e404e61f410b16fb9538e3c04bd29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ab53e27df761d28af5e77e19821175 |
| publicationDate | 2006-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006105993-A2 |
| titleOfInvention | Method for shielding functional sites or epitopes on proteins |
| abstract | Methods of site-specifically shielding one or more binding sites within a polypeptide are disclosed, comprising attaching at least one small molecular weight, water-soluble polymer to said polypeptide such that the binding site is masked by said polymer. The shielding of a binding site (e.g., epitope) as per the disclosed methods acts to either eliminate or substantially reduce the biological response induced by the interaction between said binding site and its cognate receptor, helping to refocus the biological response toward unmasked portions of the polypeptide. Pharmaceutical products generated as per the methods described herein (e.g., polymer-modified antigens and vaccine compositions comprising them), as well as the use thereof, induce a specific immune response against unmasked portions of the polypeptides when directly introduced into living vertebrate tissue, preferably a mammalian host such as a human or a non-human mammal of commercial or domestic veterinary importance, generating selective immunoprotection in said mammal. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9066983-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2354153-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010134305-A1 |
| priorityDate | 2005-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 527.