http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006104306-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc0b992b2ec6e82f45e2149cd6b07a8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0538ef588aa7ab085fa42de7bb4a3e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b46445f1ca19681cb0e55ef1d82b994 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbaf0ef5c7339bb0fa569c4abaf9a53f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c34ec2bd6620bb7df05d9e35c82114c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2005-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cc959d633f911f499fca859c9ff0bb5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1acb0a1ca0ebac0f171f1f8981c7b79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_366716e499e1a58db4c8609c9e7c9929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_412e2a5f1da00838d431845e2515d62e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae508ea8cf48a1dc23f9a1da497bb813 |
| publicationDate | 2006-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006104306-A1 |
| titleOfInvention | Non-activated polypeptides having a function of tissue regeneration and method for preparing the same |
| abstract | Non-activated tissue-regeneration polypeptides (TRPs) and the preparation methods thereof are disclosed. The TRPs contain: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be practically mass-produced by the culture of bacteria, such as recombinant E. coli, and are in a non-activated state before in vivo administration. Thus, their production cost is only a few tenths of the prior active proteins having uses similar thereto, and processes for their separation, purification, handling, storage and administration are significantly simple and convenient. The in vivo administration of the TRPs can stimulate the formation or regeneration of tissues, such as bones or cartilages, or improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisims completely different from those of prior rhBMPs or TGF-β proteins. Accordingly, the TRPs will be useful as drugs having new mechanisms. |
| priorityDate | 2005-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 209.