| abstract |
The invention relates to a compound having general formula I, wherein: X represents CH<SUB>2</SUB>, C=O, C=S or CHOH, X represents CH<SUB>2</SUB>, C=O, C=S or CHOH, R<SUB>1</SUB> represents an amino acid which is optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF<SUB>3</SUB> groups and n = 0.1 or 2, or X represents CH<SUB>2</SUB>, C=O, C=S, CHOH, R<SUB>1</SUB> represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF<SUB>3</SUB> groups and n = 0 or 1, or XR<SUB>1</SUB> represent PO<SUB>3</SUB>H or SO<SUB>3</SUB>H and n = 0.1 or 2; R<SUB>2</SUB> represents H, XR1, an alkyl group at C<SUB>1</SUB>-C<SUB>6</SUB>, an aralkyl group at C<SUB>1</SUB>-C<SUB>6</SUB> or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH<SUB>2</SUB>, a carboxylic group COOH, one or more halogen atoms, preferably fluorine, or one or more CF<SUB>3</SUB> groups; or the pharmaceutically-acceptable addition salts, isomers, enantiomers and diastereoisomers of said compound, mixtures thereof, and pharmaceutical or cosmetic compositions comprising same and the use thereof as an AGE-inhibitor drug that traps reactive carbonyl compounds. |