| abstract |
The present invention relates to compounds comprising an oxazoline or thiazoline moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, (I), wherein A1 is CH C(CH3) or N; R1 is hydrogen or halogen; R2 is (II); A2 is O or S; R3 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; R4 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl or -O-(CH2)n- NR12aR each CH2 in -O-(CH2)n-NR12aR12b being optionally substituted by one or two C1-4 alkyl; R5 is hydrogen or -O-(CH2)m-NR13aR 13b, each CH2 in-O-(CH2)m-NR13aR13 b being optionally substituted by one or two C1-4 alkyl, and at least one of R4 and R5 should be a -O-(CH2)n-NR12/13a R12/13b group. |