Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d7385a1d93fc8747ef8ee58cbb1c0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2cf992c6dea33f21525615c58ef62c0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0561084e475e9f94570115f90985aa0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_62dcb01a0ef9c9c383f6515a45b2ada7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-60 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
filingDate |
2006-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cbe050faf9cc8160475f89861f08471 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f221ff26b0524aca9fba6f9a7036b912 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3cd0f0dff544a150a40bfd5bf74850a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6609b588c25390239a10cd326c4fa771 |
publicationDate |
2006-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2006099019-A2 |
titleOfInvention |
Methods and composition related to in vivo imaging of gene expression |
abstract |
Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102393458-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11541119-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011135040-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012288442-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017206840-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2801622-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114751990-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114751990-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11634497-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9731023-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9528113-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10493162-B2 |
priorityDate |
2005-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |