| abstract |
Methods and compositions comprising CSF-1 are provided for regenerating, repairing or otherwise treating renal cells, tissues and/or organs, and more particularly, in prophylactic or therapeutic treatment of diseases or conditions associated with renal damage and/or dysfunction. In particular, CSF-1 may be particularly efficacious in treating acute renal failure. CSF-1 protein or an encoding nucleic acid may be administered to suppress, ameliorate or otherwise treat an existing renal disease or condition or to prevent, inhibit, suppress or otherwise protect against subsequent renal damage and/or renal failure. CSF-1 may also be used to regenerate or repair renal cells, tissue and/or organs ex vivo, the treated cells, tissue and/or organs then being suitable for subsequent transplantation to an animal, such as a human. |