http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006085899-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_095254868112231de34a2fc2e387c243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6ab61c1e21b4405c94b10eebd59e0c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03b2c8cc3d7c1dab4690b7ba12b285eb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P23-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate | 2005-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3067d904a5a144ea6e2e4fe7acf1fd09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7d6205fa7ab9408cdbedcb4f42ecae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_938e3187ce12e64fb3b5c24d4c302396 |
| publicationDate | 2007-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006085899-A3 |
| titleOfInvention | Method for enhancing production of isoprenoid compounds |
| abstract | The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of hydroxymethylglutaryl-CoA (HMG-CoA) in the cell, such that the level of HMG-CoA is not toxic to the cell and/or does not substantially inhibit cell growth, but is maintained at a level that provides for high-level production of mevalonate, IPP, and other downstream products of an isoprenoid or isoprenoid pathway, e.g., polyprenyl) diphosphates and isoprenoid compounds. The present invention further provides genetically modified host cells that are suitable for use in a subject method. The present invention further provides recombinant nucleic acid constructs for use in generating a subject genetically modified host cell, including recombinant nucleic acid constructs comprising nucleotide sequences encoding one or more mevalonate pathway enzymes, and recombinant vectors (e.g., recombinant expression vectors) comprising same. The present invention further provides methods for identifying nucleic acids that encode HMG-CoA reductase (HMGR) variants that provide for relief of HMG-CoA accumulation-induced toxicity. The present invention further provides methods for identifying agents that reduce intracellular accumulation of HMG-CoA. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109777815-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9273298-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163263-B2 |
| priorityDate | 2004-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.