| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a98cb1b197f761c87cd3caf32bc247e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d36e044f8832bcb83377ec9c9d99352
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7e299e3f3c8f6c1783a4473e6fb2748
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a195d83a8d452552aa3c9ae359d87cf |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-32 |
| filingDate |
2006-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0efc91943d2e2ea3e185d0311038e702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_299eac5f40b6cdc931b901f513aa25ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77da4b9544bb50b2e4162b31b1e046a8 |
| publicationDate |
2006-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006080339-A1 |
| titleOfInvention |
Process for production of 5-chloro-2,4-dihydroxypyridine |
| abstract |
A process for producing 5-chloro-2,4-dihydroxypyridine of Formula (1) comprising the steps of reacting a 5-chloro-1,3-dioxin-4-on derivative (2) represented by Formula (2) with a ketene acetal derivative (3) represented by Formula (3) to give a pyrone derivative (4) represented by Formula (4), treating the pyrone derivative (4) with an acid, and reacting the resulting product with ammonia: [Chemical formula 4] (1); [Chemical formula 1] (2) wherein R1 and R2 are as defined in the description; [Chemical formula 2] (3) wherein R3 and R4 independently represent a straight-chain or branched alkyl group having 1 to 6 carbon atoms or a silyl group substituted by a straight-chain or branched alkyl group having 1 to 6 carbon atoms; and [Chemical formula 3] (4) wherein R3 and R4 are as defined above. This process can produce 5-chloro-2,4-dihydroxypyridine which is an inhibitor of a biodegradation enzyme against an anti-malignant tumor agent 5-fluorouracil under mild conditions in a short process and generates less industrial waste, and therefore is industrially advantageous. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103086962-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7070938-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021161044-A |
| priorityDate |
2005-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |