| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b4f16ad70ddfeb0b838c113aaae408a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31c3812877d9d6605b10e94c37792c7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58873f061bd752352629dc78a479bbc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3f050738bdba871ed345ee8d08248c52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d89b8ca95cc066837db1f89678672a1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8bfd608990c37357d85146f05e42e9b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 |
| filingDate |
2005-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9de521689fd9e16c8b9f17584ad11fa6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d4a85bd53549006a7a687fc83d71519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c6fcf8219fb4a110ccb3581c1632369
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfdf701df1798e2b0bfcb0384efdefe6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbb7f2223f7a89f12ad0fdab291981cc |
| publicationDate |
2006-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006080025-A1 |
| titleOfInvention |
Process for ziprasidone using novel intermediates |
| abstract |
The present invention relates to a novel process for the preparation of high purity ziprasidone and pharmaceutically acceptable acid addition salts of ziprasidone; and solvates and hydrates thereof using novel intermediates and a purification method for ziprasidone and pharmaceutically acceptable acid addition salts of ziprasidone; and solvates and hydrates thereof. Thus, 1-(1,2-benzisothiazol-3-yl)piperazine is silylated with trimethylsilylchloride in methylene chloride in the presence of triethylamine and the solvent is distilled off to obtain silylated 1-(1,2-benzisothiazol-3-yl)piperazine. The silylated compound is reacted with 5-(2-chloroethyl)-6-chloro-oxindole in the presence of sodium carbonate to obtain ziprasidone. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009116085-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009116085-A2 |
| priorityDate |
2005-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |