| abstract |
Cells capable of differentiating into cardiac muscle cells which originate in the uterus membrane obtained from the endometrial membrane or menstrual blood or mesenchymal stem cells separated from menstrual blood, cord blood or appendages of a fetus. The above-described cells can be relatively easily acquired and obtained from, for example, menstrual blood or cord blood, which can supply a large number of HLA types, or appendages of a fetus to be discharged after the birth. When cocultured with cardiac muscle cells, these cells differentiate into cardiac muscle cells at a high frequency. Moreover, the differentiation thereof into cardiac muscle cells arises at a high frequency without demethylating (for example, by treating with 5-azacitidine) immortalized cells. By using the above-described cells, a drug for heart regeneration or a remedy for heart diseases can be provided. |