| abstract |
Disclosed herein is an industrial process for preparation of Quetiapine by the reaction of 11-piperazinyldibenzo[b,f][1,4]-thiazepine or its salt with 2-(2-chloroethoxy)ethanol in presence of an inorganic base in aqueous condition to form 11-[4-{2-(2-hydroxyethoxy)ethyl}-1-piperazinyl] dibenzo [b,f]-[1,4]thiazepine. The quetiapine free base obtained is further converted to its hemi-fumarate salt. |