| abstract |
The present invention relates to compounds of the general formula (I) wherein R1 is -OR1 , -SR1 or is a heterocycloalkyl group; R1 is lower alkyl, lower alkyl substituted by halogen, or is -(CH2)n-cycloalkyl; R2 is -S(O)2-lower alkyl or -S(O)2NH-lower alkyl; R3 is aryl or heteroaryl, which are unsubstituted or substituted by one to three substituents, selected from the group consisting of lower alkyl, lower alkoxy, CN, NO2, -C(O)-lower alkyl, -C(O)O-lower alkyl, halogen or lower alkyl substituted by halogen; n is 1 or 2; m is 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GIyT-I). |