http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006075991-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd80aa16b54e971e2436b82181298764 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_025c29729cb718693861c82d39204348 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| filingDate | 2005-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ce879fc2ed1ed8f8264564885734da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7debd6391e76b01a4ab403004504538 |
| publicationDate | 2006-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2006075991-A1 |
| titleOfInvention | Identification of genes involved in metastatic progression of cancer cells |
| abstract | The present invention relates to the discovery, identification and characterization of an eight genes that are differentially expressed as a consequence of metastatic progression in human melanoma cells. Six of the identified metastasis elevated genes (MEG genes), encode for known proteins (MEG-1 through MEG-6). However, two of the identified genes, referred to herein as MEG-7 and MEG-8, represent novel genes. The present invention relates to methods for inhibiting the metastatic potential of cancer cells through inhibition of the MEG genes/gene products, as well as diagnostic methods for determining the metastatic potential of cells. The invention further relates to novel MEG-7 and MEG-8 nucleotides, host cell expression systems, MEG-7 and MEG-8 proteins, fusion proteins, and antibodies to the MEG-7 and MEG-8. The present invention also relates to the discovery that inhibition of the mda-9 gene (also referred to as syntenin), a gene found to be upregulated in metastatic cancer cells, results in a decrease in the invasive and migratory properties of such cells. Thus, the present invention relates also to methods and compositions for inhibiting mda-9/syntenin activity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3294748-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3400070-A4 |
| priorityDate | 2005-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 348.