| abstract |
A preventive, therapeutic or improving agent for chronic obstructive pulmonary disease (COPD), cystic fibrosis or pulmonary hypertension is provided. More specifically, the invention is directed to (1) a preventive, therapeutic or improving agent for chronic obstructive pulmonary disease (COPD), cystic fibrosis or pulmonary hypertension comprising an NF-κB decoy as an active ingredient; (2) the NF-κB decoy being an oligonucleotide having a binding sequence GGGRHTYYHC (wherein R represents A or G, Y represents C or T, and H represents A, C or T); (3) the oligonucleotide in which the NF-κB binding sequence is GGGATTTCCC or GGGACTTTCC; (4) the NF-κB decoy being the oligonucleotide represented by SEQ ID NO: 3; (5) the NF-κB decoy being a double-stranded oligonucleotide; (6) the NF-κB decoy being administrated in the form of a fine powder; and (7) the NF-κB decoy fine powder being a dry powder. |