| abstract |
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDFl to the receptor. These compounds are particularly, useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis. |