| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f5087a282d97fc6d3a8d103bebd123d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b0a18f0866e58684ecb8dd952e021b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7aaab35abccf4a7bff9f7f3fdd70807f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_844b2b5c52fe1e2b4ca7064855e4e57c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e3cedc02762b6355079a9a4f8d436e5 |
| publicationDate |
2006-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006071208-A1 |
| titleOfInvention |
Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of a gnrh |
| abstract |
Controlled release compositions for controlling release of a GnRH molecule or a GnRH analog are provided. The compositions include a GnRH molecule or GnRH analog as an active agent, and a controlled release component for controlling release of the GnRH molecule or GnRH analog from the composition. The compositions provide a sustained mean steady state plasma concentration (Css) of the active agent of at least about 1.5 ng/mL for a period of at least about 48 hours when the composition is administered to a subject. In addition, the use of a controlled release component in the manufacture of a composition for the controlled release of a GnRH molecule or GnRH analog is provided. The controlled release component'is capable of providing a sustained mean steady state plasma concentration (C38) of the active agent of at. least about 1.5 ng/mL for a period of at least about 48 hours when the manufactured composition is administered to a subject. The controlled release component can include a polymeric material and/or a non-polymeric material. When the compositions are administered to a subject, for example when implanted, the compositions release the active agent in a controlled fashion. Methods for producing the compositions are also provided, as are methods of using the compositions to provide for controlled release of the GnRH molecule or GnRH analog in a subject. Preferred polymeric material is PLG or a copolymer of PLG and a PEG derivative such as methoxy PEG. Preferred non-polymeric material can be SAIB. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9433582-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8834884-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8394408-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8858963-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8506962-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8372432-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8377453-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8597681-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9198861-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9050335-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9468636-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9629837-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9956164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8658631-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8318169-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8668929-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012003230-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9539328-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741885-B1 |
| priorityDate |
2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |