abstract |
The present invention relates to a combination for use in implantable medical devices, comprising at least one signal generating agent, which in a physical, chemical and/or biological measurement or verification method leads to detectable signals, at least one material for manufacture of an implantable medical device and/or at least one component of an implantable medical device, and at least one therapeutically active agent, which in an animal or human organism fulfills directly or indirectly a therapeutic function. The invention further relates to implantable medical devices comprising such a combination, and to methods for the determination of the extent of active agent release from implantable medical devices comprising such a combination. |