| abstract |
The present invention relates to novel compounds having 3-(2-amino-6-pyrimidinyl)-4-hydroxyphenyl amine structure, as being illustrated in Formula 1, and preparations for preparation of them, and the use of them, and pharmaceutical compositions containing them at a therapeutically effective amount. The compounds according to the present invention are useful for the treatment and prevention of diseases resulting from the undesired KDR activity, for example, angiogenesis-related diseases such as cancers, psoriasis, rheumatoid arthritis, diabetic retinopathy, etc. |