abstract |
The present invention relates to peptidic and peptidomimetic compounds with the formula (X-) AA1-AA2-AA3-AA4-AA5-AA6-AA7 in which the various groups are defined in the description here below, which mimic a particular protein portion of MyD88, preventing its homodimerisation and interfering with its interaction with the TIR domain. The present invention also provides procedures for the preparation of said compounds, pharmaceutical compositions containing them and their use as medicaments, particularly for the treatment of inflammatory and autoimmune diseases. |