http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006064321-A3

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filingDate 2005-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2007-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2006064321-A3
titleOfInvention Controlled release compositions of divalproex sodium
abstract The present invention pertains to a hydrophilic matrix tablet suitable for the once-a-day administration of valproate compounds such as divalproex sodium. The tablet comprises from about 10 weight percent to about 90 weight percent of an active ingredient selected from the group consisting of valproic acid, a pharmaceutically acceptable salt or ester of valproic acid, divalproex sodium, and valpromide; from about 6 weight percent to about 18 weight percent of a pharmaceutically acceptable hydrophilic polymer, from about 0.2 weight percent to about 9.5 weight percent of a lubricant, and from about 3 weight percent to about 15 weight percent of a filler; all weight percentages based upon the total weight of the tablet dosage form. Other aspects of the invention relate to the use of this formulation in the treatment of epilepsy and to methods for manufacturing this dosage form.
priorityDate 2004-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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