| abstract |
The present invention relates to the surprising discovery that agents that increase intracellular accumulation of NADH + H+ enhance the anti-cancer effects of angiogenesis inhibitors. Furthermore, treatment of a mammal with a combination of at least one angiogenesis inhibitor and at least one agent that enhances intracellular accumulation of NADH + H+ allows for the enhanced treatment and/or prevention of ,angiogenic diseases and disorders. |