| abstract |
The invention relates to an osmotic device containing controlled-release licofelone and, optionally, rapid-release licofelone in an external coating. The inventive osmotic device delivers a controlled release of licofelone in order to maintain therapeutically-effective plasmatic levels of licofelone when it is administered once daily. The device can be used for the treatment of osteoarthritis, rheumatoid arthritis and associated inflammatory disorders. According to the invention, said devices can be used to deliver licofelone using specific release profiles combined with specific formulations. |