| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3686aa9e33f968e1f334ced6128619b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41fee97a7e947827490ace107baea40a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-027 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2005-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c874ab4ad2dd5b59e7f40d8ba6897da |
| publicationDate |
2006-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006053201-A2 |
| titleOfInvention |
Treatment of cancer by simultaneous inhibition of b-raf and restoration or mimicry of p16 ink4a activity |
| abstract |
Provided is a method for inhibiting growth of a tumor cell which comprises oncogenically activated BRAF and defective p16 INK4A by inhibiting activated BRAF and restoring functional p16 1NK4A Also provided is a method for sensitizing the foregoing tumor cell to cytotoxic or cytostatic effect of a chemotherapeutic agent or radiation by further contacting the cell with such an agent. Also provided is a method for treating cancer, especially melanoma, by simultaneously inhibiting expression or activity of activated BRAF and restoring or mimicking the activity of wild-type p16 INK4A. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013109142-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014147573-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015041533-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020212597-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015066439-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015041534-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548894-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9913844-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I603734-B |
| priorityDate |
2004-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |