| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ca485e38f8be6998b00277892cb9aef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac937257bb49850471289ef66a724289
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e216382698be1b048f3d04c3341819d3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02 |
| filingDate |
2005-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dd11e06de06ccbd192231eaf586b354
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e55c1a8e5cb863c31b81d7cdeb49a489 |
| publicationDate |
2006-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006048458-A2 |
| titleOfInvention |
Microbial strains producing sphingoid bases or derivatives thereof |
| abstract |
The present invention provides microbial strains, in particular yeast strains, that produce at least 0.1 mg per g biomass dry weight of a sphingoid base. The present invention further provides a method to obtain sphingoid base-producing microbial strains comprising incubating a population of microbial cells in the presence of a suitable concentration of a toxin, selecting cells that are resistant against said toxin, and isolating cells out of the toxin- resistant cell population that produce at least 0.1 mg per g biomass dry weight of the sphingoid base of Formula (I). Optionally, the method further comprises subjecting a population of toxin-resistant microbial cells that produce at least 0.1 mg per g biomass dry weight of the sphingoid base of Formula (I) to DNA-mediated transformation with a polynucleotide encoding an enzyme of the sphingolipid metabolic pathway. The present invention further provides a polypeptide having dihydroceramide desaturase activity obtainable form Pichia ciferrii. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102011110959-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013152913-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102012007491-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11111511-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9388439-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9404118-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013023878-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007131720-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9598711-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8372595-B2 |
| priorityDate |
2004-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |