Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba16baefd42d7a7a66ee525abb96f35b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d62fc29fcec73b4dc83df62b958ddc6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f643bf235dd782658e7b94fd1ca03c8 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2004-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8baca8a5b80db40679b0ab43d0671713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82fd2af4752502edd8f702e8013cb4bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11bd07828b9795c2b5b6791fc7333b73 |
publicationDate |
2006-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2006046951-A2 |
titleOfInvention |
Cell cycle arrest and apoptosis |
abstract |
The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that is necessary and sufficient for the HIV-1 -induced block of cellular proliferation and induction of apoptosis. Expression of vpr in CD4+ lymphocytes results in G2 arrest, followed by apoptosis. ATR, as a cellular factor that mediates Vpr-induced cell cycle arrest, is required for activation of the Breast Cancer-Associated Protein-I (BRCAI). In addition, the Growth Arrest and DNA Damage protein (GADD45) is upregulated by Vpr in an ATR-dependent manner. Posttranscriptional silencing of either ATR or GADD45 leads to nearly complete suppression of the pro-apoptotic and/or cell cycle arrest effect of Vpr. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109122581-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009207466-A |
priorityDate |
2004-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |