| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a7430b66a082478730221432ae79ca3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01P2004-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3231
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3181 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1251
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2005-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f28b98ca68af267ffef4d4efcf3e471
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16109f860653af110e41d5c20171d8c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d17bcfe7563106511a5ffe8da1e8d21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fb68fd061489b0f6185af3b85ec8e09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2631685398b9cf2ce07ed370a393f943
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_431047289683515e0fa3b16a75679b74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d529f903d2fdef3baaadd8d626af2fc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c730156a0a561012345f2f77652314bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c1c2f3d8ec6de03c987571f6beabe3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_effff761dfd41907b1136000767fd45b |
| publicationDate |
2006-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006044716-A2 |
| titleOfInvention |
CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS ('PNAs') WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER |
| abstract |
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2'-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009056837-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009056837-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013524811-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2467494-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2467494-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9295650-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9662387-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10538757-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10081542-B2 |
| priorityDate |
2004-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |