| abstract |
Aryl substituted 8-azabicyclo[3.2.1]octane compounds and analogues thereof, are provided. Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding, neuropsychiatric, reproductive and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies). |